Representative Publications:

• Strand, M., Prolla, T. A., Liskay, R. M. and Petes, T. D. (1993). Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365: 274-276.

• Fan, Q.-Q., Xu, F. and Petes, T. D. (1995). Meiosis-specific double-strand DNA breaks at the HIS4 recombination hotspot in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 1679-1688.

• Greenwell, P. W., Kronmal, S. L., Porter, S. E., Gassenhuber, J., Obermaier, B., and Petes, T. D. (1995). TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82: 823-829.

• Kirkpatrick, D. and Petes, T. D. (1997). Repair of DNA loops involves DNA mismatch and nucleotide excision repair proteins. Nature 387: 929-931.

• Moore, H., Greenwell, P. W., Liu, C.-P., Arnheim, N., and Petes, T. D. (1999). Triplet repeats form secondary structures that escape DNA repair in yeast. Proc. Nat. Acad. Sci., U. S. A. 96: 1504-1509.

• Gerton, J. L., DeRisi, J., Shroff, R., Lichten, M., Brown, P. O., and Petes, T. D. (2000). Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc. Nat. Acad. Sci., U. S. A. 97: 11383-11390.

• Petes, T. D. (2001). Meiotic recombination hot spots and cold spots. Nature Reviews: Genetics 2: 360-369.

• Craven, R. J., Greenwell, P. W., Dominska, M., and Petes, T. D. (2002). Regulation of genome stability by TEL1 and MEC1, yeast homologues of the mammalian ATM and ATR genes. Genetics 161: 493-507.

• Mieczkowski, P. A., Mieczkowska, J. O., Dominska, M., and Petes, T. D. (2003). Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisiae. Proc. Nat. Acad. Sci., U. S. A. 100: 10854-10859.

• Ben-Aroya, S., Mieczkowski, P. A., Petes, T. D., and Kupiec, M. (2004). The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. Mol. Cell 15: 47-63.

• Lemoine, F. J., Degtyareva, N. P., Lobachev, K., and Petes, T. D. (2005). Chromosomal translocations in yeast induced by low levels of DNA polymerase: a model for chromosome fragile sites. Cell 120: 587-598.
  
  
• Mieczkowski, P. A., Dominska, M., Buck, M. A., Gerton, J. L., Lieb, J. D., and Petes, T. D.   (2006). A global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae. Mol. Cell. Biol. 26: 1014-1027.
  
  
• Narayanan, V., Mieczkowski, P. A., Kim, H.-M., Petes, T. D., and Lobachev, K. S. (2006). The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. Cell 125: 1283-1296.