Joseph R. Nevins, PhD
Barbara Levine University Professor of Breast Cancer Genomics
bio  •  lab members  •  lab website

Representative Publications:

• Sears, R., Nuckolls, F., Haura, E., Taya, Y., Tamai, K., and Nevins, J. R. (2000). Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes & Dev. 14, 2105-2114.
  
  
• Leone, G., Sears, R., Huang, E., Rempel, R., Nuckolls, F., Field, S. J., Thompson, M. A., Yang, H., Fujiwara, Y., Greenberg, M. E., Orkin, S., DeGregori, J., Smith, C., and Nevins, J. R. (2001). Myc requires distinct E2F proteins to induce S phase and apoptosis. Mol Cell 8, 105-114.
  
  
• Lin, W.-C., Lin, F.-Y., and Nevins, J. R. (2001). Selective induction of E2F1 in response to DNA damage mediated by ATM-dependent phosphorylation. Genes & Dev. 15, 1833-1844.
  
  
• Huang, E., Cheng, S. H., Dressman, H., Pittman, J., Tsou, M.-H., Horng, C.-F., Bild, A., Iversen, E. S., Liao, M., Chen, C.-M., West, M., Nevins, J. R., and Huang, A. T. (2003). Gene expression predictors of breast cancer outcomes. Lancet 361, 1590-1596.
  
  
• Huang, E., Ishida, S., Pittman, J., Dressman, H., Bild, A., Kloos, M., D'Amico, M., Pestell, R. G., West, M., and Nevins, J. R. (2003). Gene expression phenotypic models that predict the activity of oncogenic pathways.   Nature Genet. 34, 226-230.
  
  
• Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stuckenberg, P. T., Shenolikar, S., Uchida, T., Counter, C. M., Nevins, J. R., Means, A. R., and Sears, R. (2004). A signaling pathway controlling Myc degradation that impacts oncogenic transformation of human cells. Nature Cell Biol. 6, 308-318.
  
  
• Pittman, J., Huang, E., Dressman, H., Horng, C.-F., Cheng, S. H., Tsou, M.-H., Chen, C.-M., Bild, A., Iversen, E. S., Huang, A. T., Nevins, J. R., and West, M. (2004). Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes. Proc. Nat'l. Acad. Sci. 101, 8431-8436.
  
  
• Giangrande, P. H., Zhu, W., Schlisio, S., Sun, X., Mori, S., Gaubatz, S., and Nevins, J. R. (2004). A role for E2F6 in distinguishing G1/S and G2/M specific transcription. Genes & Dev. 18, 2941-2951.
  
  
• Zhu, W., Giangrande, P., and Nevins, J. R. (2004). E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23, 4615-4626.
  
  
• Hallstrom, T. C. and Nevins, J. R. (2006). Jab1 is a specificity factor for E2F1-induced apoptosis. Genes & Dev. 20, 613-623.
  
  
• Bild, A. H., Yao, G., Chang, J. T., Huber, G., Wang, Q., Pittman, J., Mori, S., Potti, A., Dressman, H. K., Berchuck, A., Lancaster, J., Harpole, D., West, M., and Nevins, J. R. (2006). Signatures of oncogenic pathway deregulation in human cancers as a guide to targeted therapies. Nature 439, 353-357.
  
  
• Potti, A., Mukherjee, S., Prince, R., Dressman, H. K., Bild, A., Koontz, J., Kratzke, R., Watson, M., Kelley, M., Ginsburg, G., Harpole, D., and Nevins, J. R. (2006). A genomic strategy to refine prognosis in non-small cell lung carcinoma. N. Engl. J. Med. 355, 570-580.
  
  
• Potti, A., Dressman, H. K., Bild, A., Riedel, R. F., Chan, G., Sayer, R., Cragun, J., Cottrill, H., Gray, J., Marks, J., Kelley, M., Berchuck, A., Petersen, R., Harpole, D., Ginsburg, G. S., Febbo, P., Lancaster, J. M., and Nevins, J. R. (2006). A genomic strategy to guide the use of chemotherapeutic drugs in solid tumors. Nat. Med., in press.