John H. McCusker, PhD
Associate Professor
bio  •  lab members  •  lab website

Representative Publications:

• Sinha, H., L. David, R. C. Pascon, S. Clauder-Munster, S. Krishnakumar, M. Nguyen, G. Shi, J. Dean, R. W. Davis, P. J. Oefner, J. H. McCusker, and L. M. Steinmetz. 2008. Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics. Sept 9. [Epub ahead of print]. Abstract
  
  
• Kingsbury, J. M., and J. H. McCusker. 2008. Threonine biosynthetic genes are essential in Cryptococcus neoformans. Microbiology 154:2767-2775. Abstract
  
  
• Wei, W., J.H. McCusker, R.W. Hyman, T. Jones, Y. Ning, Z. Cao, Z. Gu, D. Bruno, M. Miranda, M. Nguyen, J. Wilhelmy, C. Komp, R. Tamse, X. Wang, P. Jia, P. Luedi, P.J. Oefner, L. David, F.S. Dietrich, Y. Li, R.W. Davis, and L.M. Steinmetz. 2007. Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Proc Natl Acad Sci USA 104(31):12825-12830. Abstract
  
  
• Kingsbury, J.M., A.L. Goldstein, and J.H. McCusker. 2006. The role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo. Eukaryotic Cell 5:816-824. Abstract

• Sinha, H., B.P. Nicholson, L.S. Steinmetz, and J.H. McCusker. 2006. Complex genetic interactions in a quantitative trait locus. PLoS Genetics 2(2):e13. Abstract

• Pascon, R.C., T.M. Ganous, J.M. Kingsbury, G.M. Cox, and J.H. McCusker. 2004. Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. Microbiology 150:3013-3023. Abstract

• Kingsbury, J.M., Z. Yang, T.M. Ganous, G.M. Cox, and J.H. McCusker. 2004. A novel chimeric spermidine synthase-saccharopine dehydrogenase ( SPE3-LYS9 ) gene in the human pathogen Cryptococcus neoformans . Eukaryotic Cell 3(3):752-763. Abstract

• Kingsbury, J.M., Z. Yang, T.M. Ganous, G.M. Cox, and J.H. McCusker. 2004. Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 °C and in vivo. Microbiology 150(5):1547-1558. Abstract

• Ito-Harashima, S., P. Hartzog, H. Sinha, and J.H. McCusker. 2002. The tRNA-Tyr gene family of Saccharomyces cerevisiae: Agents of phenotypic variation and position effects on mutation frequency. Genetics 161(4):1395-1410. Abstract

• Yang, Z., R.C. Pascon, J.A. Alspaugh, G.M. Cox, and J.H. McCusker. 2002. Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. Microbiology 148:2617–2625. Abstract

• Steinmetz, L.M., H. Sinha, D.R. Richards, J.I. Spiegelman, P.J. Oefner, J.H. McCusker, and R.W. Davis. 2002. Dissecting the complex architecture of a quantitative trait locus in a yeast model. Nature 416:326-330. Abstract

• Goldstein, A.L., and J.H. McCusker. 2001. Development of Saccharomyces cerevisiae as a model pathogen: A system for the genetic identification of gene products required for survival in the mammalian host environment. Genetics 159:499-513. Abstract

• Winzeler, E.A., D. Richards, A. Conway, A.L. Goldstein, S. Kalman, M.J. McCullough, J.H. McCusker , D.A. Stevens, L. Wodicka, D.J. Lockhart, and R.W. Davis. 1998. Direct allelic variation scanning of the yeast genome. Science 281(5380):1194-1197.

• Byron, J.K., K.V. Clemons, J.H. McCusker, R.W. Davis, and D.A. Stevens. 1995. Pathogenicity of Saccharomyces cerevisiae in complement factor five (C5) deficient mice. Infec. Immun. 63:478-485.

• McCusker, J.H. , K.V. Clemons, D.A. Stevens and R.W. Davis. 1994. Saccharomyces cerevisiae virulence phenotype as determined in CD-1 mice is associated with the ability to grow at 42ºC and form pseudohyphae. Infec. Immun. 62:5447-5455.

• McCusker, J.H., K.V. Clemons, D.A. Stevens and R.W. Davis. 1994. Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. Genetics 136:1261-1269.