Faculty and Research

Hiroaki Matsunami, PhD
Associate Professor

research • biography • lab members • publications • lab website

Representative Publications:

  • Mainland, J.D., Keller, A., Li, Y.R, Zhou, T. Snyder, L.L., Moberly, A.H., Adipietro, K.A., Liu, W.L.L., Zhuang, H., Zhan, S., Lee, S.S., Lin, A., and H. Matusunami. (2014). The missense of smell: Functional variability in the human odorant receptor repertoire. Nat Neurosci, Jan;17(1):114-120. [Epub 2013 Dec 8].

  • Jiang, Y., Gong, N.N. and H. Matusnami. (2014). Astringency: A more stringent definition. Chem Senses, Jul;39(6):467-469. [Epub 2014 May 23].
  • Li, Y.R., and H. Matsumani (2013). Unfolding the mystery of olfactory receptor gene expression. Dev Cell, 27:128-129.
  • Keydar, I., et al. (2013). General olfactory sensitivity database (GOSdb): Candidate genes and their genomic variations. Hum Mutat, Jan;34(1):32-41. [Epub 2012 Oct 11].

  • Adipietro, K.A., J.D. Mainland, and H. Matsunami. (2012). Functional evolution of mammalian odorant receptors. PLoS Genet, 8(7):e1002821.

  • McRae, J.F., et al. (2012). Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol. Chem Senses, 37(7):585-593.

  • Wu, L., et al., (2012). Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. J Biol Chem, 287(26):22287-22294.

  • Lunde, K., et al. (2012). Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. PLoS One, 7(5):e35259.

  • Mainland, J. and H. Matsunami. (2012). RAMP like proteins: RTP and REEP family of proteins. Adv Exp Med Biol, 744:75-86.

  • Duan, X., et al. (2012). Crucial role of copper in detection of metal-coordinating odorants. Proc Natl Acad Sci U S A, 109(9):3492-3497.

  • Michaloski, J.S., et al. (2011). Common promoter elements in odorant and vomeronasal receptor genes. PLoS One, 6(12):e29065.

  • Dey, S. and H. Matsunami. (2011). Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. Proc Natl Acad Sci U S A, 108(40):16651-16656.

  • Chamero, P., et al. (2011). G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. Proc Natl Acad Sci U S A, 108(31):12898-12903.

  • Horio, N., et al. (2011). Sour taste responses in mice lacking PKD channels. PLoS One, 6(5):e20007.

  • Dey, S., S. Zhan, and H. Matsunami. (2011). Assaying surface expression of chemosensory receptors in heterologous cells. J Vis Exp, (48):e2405.

  • Li, Y.R. and H. Matsunami (2011). Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling. Sci Signal, 4(155): ra1.

  • Ishimaru, Y., et al. (2010). Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J, 24(10):4058-4067.
  • Zhuang, H., Chien, M.S., Matsunami, H. (2009). Dynamic functional evolution of an odorant receptor for sex-steroid-derived odors in primates. Proc Natl Acad Sci U S A, 106:21247-21251.

  • Grosmaitre, X., Fuss, S.H., Lee, A.C., Adipietro, K.A., Matsunami, H., Mombaerts, P., Ma, M. (2009). SR1, a mouse odorant receptor with an unusually broad response profile. J Neurosci, 29:14545-14552.

  • Wilson, D.A., Baker, H., Brunjes, P., Gilbertson, T.A., Hermer, L., Hill, D.L., Matsunami, H., Meredith, M., Mistretta, C.M., Smeets, M.A., Stowers, L., Zhuang, H. (2009). Chemoreception scientists gather under the Florida sun: The 31st Annual Association for
    Chemoreception Sciences meeting. Ann N Y Acad Sci, 1170 Suppl 1:1-11.

  • Matsunami, H., Mainland, J.D., Dey, S. (2009). Trafficking of mammalian chemosensory receptors by receptor-transporting proteins. Ann N Y Acad Sci, 1170: 153-156.

  • Mainland, J.D., and Matsunami, H. Taste perception: How sweet it is (to be transcribed by you). (2009). Curr Biol, 19:R655-6. Review.

  • Ishimaru, Y., and Matsunami, H. (2009). Transient receptor potential (TRP) channels and taste sensation. J Dent Res, 88:212-218. Review.

  • Saito, H., Chi, Q., Zhuang, H., Matsunami, H., Mainland, J.D. Odor coding by a mammalian receptor repertoire. (2009). Sci Signal, 2:ra9.

  • Sun, L., Wang, H., Hu, J., Han, J., Matsunami, H., Luo, M. (2009). Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. Proc Natl Acad Sci U S A, 106:2041-2046.

  • Katz, D.B., Matsunami, H., Rinberg, D., Scott, K., Wachowiak, M., Wilson, R.I. (2008). Receptors, circuits, and behaviors: new directions in chemical senses. J Neurosci, 28:11802-11805. Review.

  • Zhuang, H., and Matsunami, H. (2008). Evaluating cell-surface expression and measuring activation of mammalian ordorant receptors in heterologous cells. Nat Protoc, 3: 1402-1413.

  • Inada, H., Kawabata, F., Ishimaru, Y., Fushiki, T., Matsunami, H., Tominaga, M. (2008). Off-response property of an acid-activated cation channel complex PKD1L3 - PKD2L1. EMBO Rep, 9:690-697.

  • Kataoka, S., Yang, R., Ishimaru, Y., Matsunami, H., Sevigny, J., Kinnamon, J.C., Finger, T.E. (2008). The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses, 33:243-254.

  • Keller, A., Zhuang, H., Chi, Q., Vosshall, L.B., Matsunami, H. (2007). Genetic variation in a human odorant receptor alters odour perception. Nature, 449: 468-472.

  • Hu, J., Zhong, C., Ding, C., Chi, Q., Walz, A., Mombaerts, P., Matsunami, H., Luo, M. (2007). Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. Science, 317:953-957.

  • Zhuang, H., and Matsunami, H. Synergism of accessory factors in functional expression of mammalian odorant receptors. (2007). J Biol Chem, 282:15284-15293.
  • Ishimaru, Y., Inada, H., Kubota, M., Zhuang, H., Tominaga, M., Matsunami, H. (2006). Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A, 103:12569-12574.

  • Abaffy, T., Matsunami, H., Luetje, C.W. (2006). Functional analysis of a mammalian odorant receptor subfamily. J Neurochem, 97:1506-1518.

  • Saito, H., Kubota, M., Roberts, R.W., Chi, Q., and Matsunami, H. (2004). RTP family members induce functional expression of mammalian odorant receptors. Cell, 119:679-691.
  • Mizrahi, A., Matsunami, H., and Katz, L.C. (2004). An imaging-based approach to identify ligands for olfactory receptors. Neuropharmacology, 47:661-668.
  • Matsunami, H., and Amrein, H. (2004). Taste perception: how to make a gourmet mouse. Curr Biol, 14: R118-120.
  • Matsunami, H., and Amrein, H. (2003). Taste and pheromone perception in mammals and flies. Genome Biol, 4:220.
  • Montmayeur, J. P., and Matsunami, H. (2002). Receptors for bitter and sweet taste. Curr Opin Neurobiol, 12:366-371.
  • Montmayeur, J.P., Liberles, S.D., Matsunami, H. and Buck, L.B. (2001) A candidate taste receptor gene near a sweet taste locus. Nature Neurosci, 4:492-8.
  • Matsunami H., Montmayeur, J.P. and Buck, L.B. (2000). A family of candidate taste receptors in human and mouse. Nature, 404:601-604.
  • Matsunami, H. and Buck, L.B. (1997). A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell, 90:775-784.