Nayun Kim, PhD
Research Assistant Professor
research • publications

Representative Publications:

• Kim, N., Mudrak, S., and Jinks-Robertson, S. 2011 "The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites." DNA Repair 10:1262 - 71.
  
  
• Kim, N.* and Jinks-Robertson, S. 2011 "Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast." DNA Repair 10:953-60. (*Corresponding Author)
  
  
• Kim, N., Shar-yin N. Huang, Williams, J. S., Li, Y. C., Clark, A., Cho, J-E., Kunkel, T. A., Pommier, Y. and Jinks-Robertson, S. "Mutagenic processing of ribonucleotides in DNA by yeast Topoisomerase I." Science 332:1561 – 1564, 2011. (This paper was highlighted in Science 332: 1510 – 1511, 2011)
  
  
• Lippert, M. J.*, Kim, N.*, Cho, J. E., Larson, R. P., Schoenly, N. E., O’Shea, S. H., and Jinks-Robertson, S. “Role for topoisomerase 1 in transcription-associated mutagenesis in yeast” PNAS 108:698 – 703, 2011. (*Co-first Authors.) (This paper was highlighted in Nature Reviews Genetics 12:156, 2011
  
  
• Kim, N. and Jinks-Robertson, S. “Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair.”  Molecular and Cellular Biology 30:3206-3215, 2010.
  
  
• Kim, N. and Jinks-Robertson, S. “dUTP incorporation into genomic DNA is linked to transcription in yeast.” Nature 459:1150–1153, 2009.
  
  
• Kim, N., Abdulovic, A., Gealy, R., Lippert, M., and Jinks-Robertson, S. "Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication" DNA Repair 6:1285-1296, 2007.
  
  
• Abdulovic, A., Kim, N., and Jinks-Robertson, S. "Mutagenesis and the three R's in yeast" DNA Repair 5:409-21, 2006.
  
  
• Marini, F., Kim, N., Schuffert, A., and Wood, R. "POLN, a nuclear POLA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308" The Journal of Biological Chemistry 278:32014-32019, 2003.
  
  
• Michael, N., Shen, H. M., Longerich, S., Longacre, A., Kim, N., and Storb, U. "The E-box motif, CAGGTG, is an enhancer of somatic hypermutation without enhancing transcription." Immunity 19:235-242, 2003.
  
  
• Kim, N., Martin, T. E., Simon, M. C., and Storb, U. "The transcription factor Spi-B is not required for somatic hypermutation" Molecular Immunology 39:577-583, 2003.
  
  
• Michael, N., Martin, T. E., Nicolae, D., Kim, N., Padjen, K., Zhan, P., Nguyen, H., Pinkert, C., and Storb, U. "Effects of sequence and structure on the hypermutability of immunoglobulin genes." Immunity 16:123-134, 2002.
  
  
• Shen, H. M., Michael, N., Kim, N., and Storb, U. "The TATA binding protein, c-MYC and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells."  International Immunology 12:1085 1093, 2000.
  
  
• Storb, U., Shen, H. M., Michael, N., and Kim, N. "Somatic hypermutation of immunoglobulin and non-immunoglobulin genes" Philosophical Transactions of the Royal Society 356:13-20, 2000.
  
  
• Storb, U., Peters, A., Kim, N., Shen, H.M., Bozek, G., Michael, N., Hackett, Jr, J., Klotz, E., Reynolds, J.D., Loeb, L.A., and Martin, T.E. "Molecular aspects of somatic hypermutation of immunoglobulin genes." Cold Spring Harbor Symposia on Quantitative Biology 64:227-34, 1999.
  
  
• Kim, N., Bozek, G., Lo, J. C., Storb, U. "Different mismatch repair deficiencies all have the same effects on somatic hypermutation:Intact primary mechanism accompanied by secondary modifications." Journal of Experimental Medicine 190:21-30, 1999.
  
• Kim, N., and Storb, U. "The role of DNA repair in somatic hypermutation of immunoglobulin genes." Journal of Experimental Medicine 187:1729-1733, 1998.
  
• Storb, U., Peters, A., Klotz, E., Kim, N., Shen, H. M., Kage, K., Rogerson, B., and Martin, T. E. "Somatic hypermutation of immunoglobulin genes is linked to transcription." Current Topics in Microbiology and Immunology 229:11-18, 1998.
  
  
• Storb, U., Peters, A., Klotz, E., Kim, N., Shen, H. M., Rogerson, B., and Martin, T. E. "Cis-acting sequences that affect somatic hypermutation of Ig genes." Immunological Reviews 162:153-160, 1998.
   
• Kim, N., Kage, K., Matsuda, F., Lefranc, M.-P., and Storb, U. "B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes."  Journal of Experimental Medicine 186:413-419, 1997.
  
  
• Zent, C., Kim, N., Hiebert, S., Zhang, D. E., Tenen, D. G., Rowley, J. D., and Nucifora, G. "Rearrangement of the AML1/CBFA2 gene in Myeloid leukemia with the 3;21 translocation:  Expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties." Current Topics in Microbiology and Immunology 211:243-252, 1996.