2006 - Louisiana State University
2012 - University of Colorado
PhD, Cancer Biology
One hallmark of cancer is the ability of cells to activate invasion and metastasis. Epithelial-to-mesenchymal transition (EMT) is a term used to describe the changes which occur that give epithelial cancer cells the means to invade and survive in the circulatory system. Gene expression changes that occur during EMT include alterations in cell adhesion molecules that modify interactions between tumor cells and the tumor microenvironment. My research interests include understanding what makes cancer cells undergo EMT, including signaling from the tumor microenvironment, and characterizing tumor cells in the circulatory system to better understand EMT.
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.
Ware KE, Hinz TK, Kleczko E, Singleton KR, Marek LA, Helfrich BA, Cummings CT, Graham DK, Astling D, Tan AC, Heasley LE.
Oncogenesis. 2013 Mar 25;2:e39. doi: 10.1038/oncsis.2013.4. PMID:23552882.
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Pawlus MR, Wang L, Ware KE, Hu CJ.
Mol Cell Biol. 2012 Nov;32(22):4595-610. doi: 10.1128/MCB.00724-12. Epub 2012 Sep 10. PMID:22966206.
Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells.
Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, Marek L, Frederick BA, Raben D, Heasley LE.
Clin Cancer Res. 2011 Aug 1;17(15):5016-25. doi: 10.1158/1078-0432.CCR-11-0050. Epub 2011 Jun 14. PMID:21673064.
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.
Ware KE, Marshall ME, Heasley LR, Marek L, Hinz TK, Hercule P, Helfrich BA, Doebele RC, Heasley LE.
PLoS One. 2010 Nov 29;5(11):e14117. doi: 10.1371/journal.pone.0014117. PMID:21152424.
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.
Keating AK, Kim GK, Jones AE, Donson AM, Ware KE, Mulcahy JM, Salzberg DB, Foreman NK, Liang X, Thorburn A, Graham DK.
Mol Cancer Ther. 2010 May;9(5):1298-307. doi: 10.1158/1535-7163.MCT-09-0707. Epub 2010 Apr 27. PMID:20423999.
The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer.
Kono SA, Marshall ME, Ware KE, Heasley LE.
Drug Resist Updat. 2009 Aug-Oct;12(4-5):95-102. doi: 10.1016/j.drup.2009.05.001. Epub 2009 Jun 4. Review. PMID:19501013.
Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells.
Marek L, Ware KE, Fritzsche A, Hercule P, Helton WR, Smith JE, McDermott LA, Coldren CD, Nemenoff RA, Merrick DT, Helfrich BA, Bunn PA Jr, Heasley LE.
Mol Pharmacol. 2009 Jan;75(1):196-207. doi: 10.1124/mol.108.049544. Epub 2008 Oct 10. PMID:18849352.