||2001 - BS, Microbiology, University of Iowa
2012 - PhD, University of Minnesota
Dengue virus is an arthropod-borne human pathogen that infects between 50-100 million people annually and represents an emerging global health threat. Dengue virus infection can potentially lead to life-threatening illness such as dengue hemorrhagic fever or dengue shock syndrome. There is currently no vaccine or anti-viral therapeutic available for preventing or treating dengue virus infection.
Dengue virus relies heavily on host cell factors to complete the process of virus replication. Recent genome-scale RNAi screens from our lab and others have identified host factors that are required for the efficient replication of several members of the flavivirus family, including dengue virus. One goal of my research is to identify small-molecule inhibitors of these host factors and determine whether these inhibitors possess anti-dengue viral activity. In addition, I seek to investigate the mechanisms by which dengue virus utilizes these host factors to promote its own replication. This work will further our understanding of dengue virus replication at the molecular level and may lead to the development of anti-viral therapies.
Phillips, S.L., Cygnar, D., Thomas, A., and Bresnahan, W.A. Interaction between the human cytomegalovirus tegument proteins UL94 and UL99 is essential for virus replication. J. Virol. 86(18): 9995-10005.
Phillips, S.L. and Bresnahan, W.A. 2011. The human cytomegalovirus tegument protein UL94 is essential for secondary envelopment. J. Virol. 86(5): 2523-32.
Phillips, S.L. and Bresnahan, W.A. 2011. Identification of binary interactions between human cytomegalovirus virion proteins. J. Virol. 85(1):440-7.
Kronemann, D., Hagemeier, S.R., Cygnar, D., Phillips, S., and Bresnahan, W.A. 2010. Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. J. Virol. 84(18):9649-54.
Hussong, S., Kapphahn, R., Phillips, S., Maldonado, M., and Ferrington, D.A. 2010. Immunoproteasome deficiency alters retinal proteasome’s response to stress. J. Neurochem. 113(6):1481-90.
Ianzini, F., Domann, F.E., Kosmacek, E.A., Phillips, S.L., and Mackey, M.A. 2007. Human glioblastoma U87MG cells transduced with a dominant negative p53 (TP53) adenovirus construct undergo radiation-induced mitotic catastrophe. Radiat. Res. 168(2):183-92.
Ianzini F., Bertoldo A., Kosmacek E.A., Phillips S.L., and Mackey M.A. 2006. Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells. 2006 Cancer Cell Int. 6(1):11.
Klingelhutz A.J., Qian Q, Phillips S.L., Gourronc F.A., Darbro B.W., Patil S.R. 2005. Amplification of the chromosome 20q region is associated with expression of HPV-16 E7 in human airway and anogenital epithelial cells. Virology. 340(2)237-44.
Ault, K.A., Allen, H.K., Phillips, S.L., Zimmerman, B.M., and Klingelhutz, A.J. 2005. Telomerase Activity as a Potential Diagnostic Marker for Triage of Abnormal Pap Smears. J. Low. Genit. Tract Dis. 9(2):93-99.
Zabner, J., Karp, P., Sailer, M., Phillips, S.L., Mitchell, C., Saavedra, M., Welsh, M., and Klingelhutz, A. 2003. Development of Cystic Fibrosis and Non-Cystic Fibrosis Airway Cell Lines. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:844-854.
Duffy, C.L., Phillips, S.L., and Klingelhutz, A.J. 2002 Microarray Analysis Identifies Differentiation-Associated Genes Regulated by Human Papillomavirus Type 16 E6. Virology. 314(1):196-205.
Sprague, D.L., Phillips, S.L., Mitchell, C.J., Berger, K.L., Lace, M., Turek, L.P., and Klingelhutz, A.J. 2002. Telomerase Activation in Cervical Keratinocytes Containing Stably Replicating Human Papillomavirus Type 16 Episomes. Virology. 301(2):247-54.