Gaddiel Galarza Munoz B.S. - University of Puerto Rico Ph.D. - Institute of Neurobiology, University of Puerto Rico Research Interests
B.S. - University of Puerto Rico
Ph.D. - Institute of Neurobiology, University of Puerto Rico
Alternative splicing is an RNA modifying process that equips cells with phenotypic complexity in the form of regulation of genetic expression and diversification of the proteome repertoire. Recent estimates using high-throughput sequencing technologies posit that over 90% of the human transcriptome is alternatively processed. Consequently, defects in splicing cause a wide array of human diseases. My research interests lie at the interface of alternative splicing and human disease, with particular focus on targeting alternative splicing for therapeutic intervention.
My current research project is centered on regulation of alternative splicing of the interleukin-7 receptor (IL7R). This receptor plays a central role in the homeostatic regulation of T cells, and its dysfunction underlies the etiology of numerous immune disorders. I am working towards elucidating the regulatory landscape controlling IL7R splicing with the long-term goal of strategically tailoring its splicing to restore T cell-driven immunity in autoimmune disease conditions.
Galarza-Muñoz G, Soto-Morales S, Holmgren M, and JJC Rosenthal (2011). Physiological adaptation of an Antarctic Na+/K+-ATPase to the cold. Journal of Experimental Biology 214, 2164-2174.
Galarza-Muñoz G, Soto-Morales S, Holmgren M, and JJC Rosenthal (2013). Sequence determinants of cold adaptation in an Antarctic Na+/K+-ATPase. In progress.