Duke University Medical Center
research The Garcia-Blanco Lab
  LAB MEMBERS

Crisanto Maglaque Lopez
Research Fellow

Cristano Lopez

E-mail: crisanto.lopez@duke-nus.edu.sg
Phone: +65-65165925

Education

BS: University of the Philippines-Diliman
MS: École Nationale Supérieure des Industries Agricoles et Alimentaires-SIARC
Dr. rer. nat.: Friedrich-Schiller-Universität Jena


Research Projects and Interests

Cris is mainly interested in understanding the mechanisms of human host-pathogen interactions. Specifically, he is focused on identifying and characterizing proteins on the surface of human cells that act as receptors for pathogens. He is currently working on a project to validate the role of human cell surface proteins identified in the genome-wide siRNA screen as receptors or co-receptors for the entry of dengue virus (DENV). In addition, Cris is also working on the elucidation of the DENV RNA secondary and tertiary structures, together with their regulation by and association with viral and human proteins.

Identification and characterization of the host cell receptors or co-receptors and understanding the mechanisms of DENV RNA conformational changes will provide insights into the mechanisms of DENV entry and replication.  Ultimately, they will form the basis for rational structure-based drug design that can interfere with DENV binding to and propagation in target cells.

Both of Cris’ projects are in collaboration with Dr. Sheemei Lok (http://www.duke-nus.edu.sg/content/lok-shee-mei).

 

Publications

Please visit www.ncbi.nlm.nih.gov/pubmed/?term=crisanto+lopez

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