Bryan R. Cullen, PhD
James B. Duke Professor
bio  •  lab members  •  lab website

Representative Publications:

• Zeng, Y., Wagner, E.J., and Cullen, B.R. (2002). Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9:1327-1333.

• Bogerd, H.P., Doehle, B.P., Wiegand, H.L., and Cullen, B.R . (2004). A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor. Proc. Natl. Acad. Sci. USA 101:3770-3774.

• Cai, X., Hagedorn, C.H., and Cullen, B.R . (2004).   Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10:1957-1966.

• Zeng, Y., Yi, R., and Cullen, B.R. (2005).   Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme drosha.   EMBO J. 24:138-148.

• Cai, X., Lu, S., Zhihong, Z., Gonzalez, C.M., Damania, B., and Cullen, B.R . (2005).   Kaposi's sarcoma-associated herpesvirus expresses an array of novel viral microRNAs in latently infected cells. Proc. Natl. Acad. Sci. USA 102:5570-5575.

• Cai, X., Schäfer, A., Lu, S., Bilello, J.P., Desrosiers, R.C., Edwards, R., Raab-Traub, N., and Cullen, B.R. (2006). Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathogens 2:e23.

• Bogerd, H.P., Wiegand, H.L., Hulme, A.E., Garcia-Perez, J.L., O'Shea, K.S., Moran, J.V., and Cullen, B.R. (2006). Cellular inhibitors of long interspersed element 1 and Alu retrotransposition. Proc. Natl. Acad. Sci. USA 103:8780-8785.
  
  
• Lin, J. and Cullen, B.R. (2007). Analysis of the interaction of primate retroviruses with the human RNA interference machinery. Journal of Virology 81:12218-12226.
  
  
• Gottwein, E., Mukherjee, N., Sachse, C., Frenzel, C., Majoros, W.H., Chi, J.-T.A., Braich, R., Manoharan, M., Soutschek, J., Ohler, U., and Cullen, B.R. (2007). A viral microRNA functions as an ortholog of cellular miR-155. Nature 450:1096-1099.