Representative Publications:

• Puria, R., Zurita-Martinez, S.A., and Cardenas, M.E. (2008). Nuclear translocation of Gln3 in response to nutrient signals requires Golgi to endosome trafficking in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 105:7194-7199.
  This study was featured on the cover and highlighted by a commentary in the same PNAS issue. It was also highlighted in the editor's choice section of Science Signaling: A.M. VanHook, Route to Specificity. Sci. Signal. 1, ec199 (2008).
  
  
• Rohde, J.R., Bastidas, R., Puria, R., and Cardenas, M.E. (2008). Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr. Opin. Microbiol. 2:153-160.
  
  
• Rutherford, J.C., Chua, G., Hughes, T., Cardenas, M.E., and Heitman J. (2008). A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. Mol. Biol. Cell. Apr. 23 [Epub ahead of print].
  
  
• Zurita-Martinez, S.A., Puria, R., Pan, X., Boeke, J.D., and Cardenas, M.E. (2007). Efficient Tor signaling requires a functional Class C Vps protein complex in Saccharomyces cerevisiae. Genetics 107:2139-2150.
  
  
• Bahn, Y-S., Xue, C., Idurm, A., Rutherford, J.C., Heitman, J., and Cardenas, M.E. (2007). Sensing the environment: Lessons from fungi. Nat. Rev. Microbiol. 5:57-69.
  
  
• Zurita-Martinez, S.A., and Cardenas, M.E. (2005). TOR and cyclic AMP-Protein Kinase A: Two parallel pathways regulating expression of genes required for cell growth. Eukaryot. Cell 4:63-71.

• Rohde, J.R., Campbell, S., Cutler, N.S., Zurita-Martinez, S.A., Ashe, M., and Cardenas, M.E. (2004). TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase effectors. Mol. Cell Biol. 24:8332-8341.
  
  
• Rohde, J. and Cardenas, M.E. (2003). The TOR pathway links nutrient sensing to histone acetylation. Mol. Cell Biol. 23:629-635.
  
  
• Rohde, J., Heitman, J., and Cardenas, M.E. (2001). The TOR kinases link nutrient sensing to cell growth. J. Biol. Chem. 276:9583-9586.
  
  
• Cutler, N.S., Pan, X., Heitman, J., and Cardenas, M.E. (2001). The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol. Biol. Cell 12:4103-4113.
  
  
• Cardenas, M. E., Cutler, N. S., Lorenz M.C., Di Como, C.J., and Heitman, J. (1999). The TOR signaling cascade regulates gene expression in response to nutrients. Genes and Development 13:3271-3279.
  
  
• Alarcon, C.M., Heitman, J., and Cardenas, M.E. (1999). Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Molecular Biology of the Cell 10:2531-2546.
  
  
• Cardenas, M.E., Crux, M.C., Del Poeta, M., Chung, N., Perfect, J.R., and Heitman, J. (1999). Antifungal actions of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clinical Microbiology Reviews 12:583-611.
  
  
• Cutler, N.S., Heitman, J., and Cardenas, M.E. (1999). TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Molecular and Cellular Endocrinology 155:135-142.